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促甲状腺素受体抗体，TSHR抗体
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详细信息
中文名称：促甲状腺素受体抗体，TSHR抗体
英文名称：Anti-TSHR
货号：BYK-2087R
克隆类型：polyclonal or monoclonal
抗体来源：Rabbit or Mouse
性状：Lyophilized or Liquid
产品类型：一抗
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
标记物：可以提供抗体相对应的 HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 等标记物抗体，详情请询！
促甲状腺素受体抗体，TSHR抗体 详细介绍：
The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone（TSH） receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland （De Felice et al. 2004）. The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin （Tg）, thyroid peroxidase （TPO）, and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism （Graves disease） or hypothyroidism （Hashimoto thyroiditis） when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor （Rapoport and McLachlan, 2001; Davies et al., 2002）. Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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