Anti-ARA24抗体,雄激素受体相关蛋白24抗体说明书 >>>>>>>点击查看
Rabbit Anti-ARA24
Catalog Number : BYK-3751R
Quantity size : 100ug （0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide）
Background: Ran （ras-related nuclear protein） is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 （RCC1）. Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor （AR） coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease （X-linked spinal and bulbar muscular atrophy）. Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Specificity :
– Anti-ARA24 is a rabbit polyclonal antibody unconjugated
– specific for ARA24 of mo,rat,hu
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 26kDa
Anti-ARA24抗体,雄激素受体相关蛋白24抗体说明书Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– IP=1:20-100
– IF=1:100-500
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Anti-ARA24抗体,雄激素受体相关蛋白24抗体说明书Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
