CDK-8 Human
Cyclin-Dependent Kinase 8 Human Recombinant
人细胞周期蛋白依赖激酶8
Catalog No. PKA-310

Synonyms:
Cell division protein kinase 8, EC 2.7.11.22, EC 2.7.11.23, Protein kinase K35, CDK-8, K35, MGC126074, MGC126075, CDK8.

Introduction:
CDK8 （cyclin-dependent kinase 8; protein kinase K35; CDK8 protein kinase; cell division protein kinase 8; K35） is a member of the cyclin-dependent protein kinase （CDK） family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain （CTD） of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH （TFIIH）, thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Description:
Cyclin-Dependent Kinase 8 Human Recombinant is expressed in E. coli as a full-length protein fused to a proprietary 16-Kd tag （a 6xHis tag is located at the very N-terminal end）.
CDK8 is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Formulation:
CDK8 is supplied at 0.1mg/ml in a buffer containing 25 mM HEPES, pH 7.9, 125mM KCI, 0.5% TX-100 and 50% glycerol.

Application:
CDK-8 can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments.
The biological activity of this product has not yet been tested.

Storage Conditions:
Store at 4°C if entire vial will be used within 1-2 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles.

Purity:
Greater than 90% as determined by SDS-PAGE.

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

相关产品：

ACVR1B 人活化素A受体-IB PKA-366 Recombinant Human Activin A Receptor, Type IB
ADK 人腺苷激酶 PKA-367 Recombinant Human Adenosine Kinase
AK2 人腺苷酸激酶2 PKA-260 Recombinant Human Adenylate Kinase 2
AK3L1 人腺苷酸激酶23L1 PKA-346 Recombinant Human Adenylate Kinase 3 Like 1
AKT-1 人苏氨酸蛋白激酶 PKA-305 Recombinant Human AKT1
ATF-2 人活化转录因子-2 PKA-306 Recombinant Human Activating Transcription Factor-2
AURKA 人极光激酶A PKA-350 Recombinant Human Aurora Kinase A
AURKB 人极光激酶B PKA-355 Recombinant Human Aurora Kinase B
CCNC 人细胞周期蛋白-C PKA-311 Recombinant Human cyclin-C
CCNH 人细胞周期蛋白-H PKA-364 Recombinant Human Cyclin-H
CDK2AP1 人细胞周期蛋白依赖性激酶相关蛋白12 PKA-362 Recombinant Human Cyclin-Dependent Kinase 2 Associated Protein 1
CDK4 人细胞周期蛋白依赖激酶4 PKA-325 Recombinant Human cyclin-dependent kinase 4
CDK8 人细胞周期蛋白依赖激酶8 PKA-310 Recombinant Human cyclin-dependent kinase 8
c-erbB-2 人受体酪氨酸蛋白激酶 PKA-340 Recombinant Human c-erbB2
cfPKAR-1a 人蛋白激酶A调节亚基-1α PKA-202 Recombinant Protein Kinase A regulatory subunit-1 alpha
CIB1 人钙和整合素结合1 PKA-345 Recombinant Human Calcium and Integrin Binding 1
C-JUN 人激活蛋白1 PKA-323 Recombinant C-JUN
CK2b  人酪蛋白激酶2b PKA-223 Recombinant Human Casein Kinase 2 beta
CK2b Active 人酪蛋白激酶2b PKA-209 Recombinant Human Casein Kinase 2 beta Active
CK2h 人酪蛋白激酶2b 全酶 PKA-211 Recombinant Human Casein Kinase 2 Holoenzyme
CKS2 人CDC28蛋白激酶2 PKA-258 Recombinant Human CDC28 protein kinase 2
CSNK2A1 人酪蛋白激酶2a PKA-208 Recombinant Human Casein Kinase 2 alpha
CSNK2A1 His 人蛋白激酶酪蛋白激酶2a PKA-225 Recombinant Human Protein kinase Casein Kinase 2 alpha, His Tag
C-SRC 人Csk/Src 分子C 端激酶 PKA-317 Recombinant Human C-SRC
EGFR Sf9 人表皮生长因子受体 PKA-344 Recombinant Human Epidermal Growth Factor Receptor-Sf9  （ErbB1）
EGFR Sf9 人表皮生长因子受体 PKA-335 Recombinant Human Epidermal Growth Factor Receptor-Sf9  （ErbB1）, Active
ELK-1  PKA-309 Recombinant Human ELK-1
ErbB2 人酪氨酸激酶2 PKA-343 Recombinant Human Tyrosine Kinase ErbB-2
ErbB3 人酪氨酸激酶3 PKA-342 Recombinant Human Tyrosine Kinase ErbB-3
ERK1/MAPK3  PKA-212 Recombinant Human ERK1/MAPK3 Active Enzyme
ERK1/MAPK3  PKA-213 Recombinant Human ERK1/MAPK3 Inactive Enzyme
MAPK1 Active 人丝裂原活化蛋白激酶1 PKA-214 Recombinant Human Mitogen-Activated Protein Kinase 1, Active
MAPK1 人丝裂原活化蛋白激酶1 PKA-215 Recombinant Human Mitogen-Activated Protein Kinase 1
MAPK1 His 人丝裂原活化蛋白激酶1 PKA-360 Recombinant Human Mitogen-Activated Protein Kinase 1 His Tag
FAK1 人活动粘着斑激酶 PKA-312 Recombinant Human Active Focal Adhesion Kinase
FGFR1 人成纤维细胞生长因子受体1 PKA-230 Recombinant Human Fibroblast Growth Factor Receptor-1
FGFR2 人成纤维细胞生长因子受体2 PKA-231 Recombinant Human Fibroblast Growth Factor Receptor-2
FGFR3 人成纤维细胞生长因子受体3 PKA-232 Recombinant Human Fibroblast Growth Factor Receptor-3
FGFR4 人成纤维细胞生长因子受体4 PKA-233 Recombinant Human Fibroblast Growth Factor Receptor-4
Flavokinase 人核黄素激酶 PKA-352 Recombinant Human Riboflavin Kinase
FLT1 人血管内皮生长因子受体1 PKA-240 Recombinant Human Vascular Endothelial Growth Factor receptor-1
FLT1 D3 人血管内皮生长因子受体1 PKA-234 Recombinant Human Vascular Endothelial Growth Factor receptor-1 D1-3
FLT1 D3 His 人血管内皮生长因子受体1 PKA-338 Recombinant Human Vascular Endothelial Growth Factor receptor-1  D1-3, His Tag
FLT1 D4 人血管内皮生长因子受体1 PKA-235 Recombinant Human Vascular Endothelial Growth Factor receptor-1 D1-4
FLT1 D5 人血管内皮生长因子受体1 PKA-239 Recombinant Human Vascular Endothelial Growth Factor receptor-1 D1-5
FLT1 D7 人血管内皮生长因子受体1 PKA-241 Recombinant Human Vascular Endothelial Growth Factor receptor-1 D1-7
FLT1 His 人血管内皮生长因子受体1 PKA-354 Recombinant Human Vascular Endothelial Growth Factor receptor-1 His Tag
FLT4 人血管内皮生长因子受体3 PKA-244 Recombinant Human Vascular Endothelial Growth Factor receptor-3
FLT4 Fc 人血管内皮生长因子受体3 PKA-245 Recombinant Human Vascular Endothelial Growth Factor receptor-3 Fc Chimera
GALK1 人半乳糖激酶1 PKA-264 Recombinant Human Galactokinase 1
GCK 人己糖激酶-4 PKA-236 Recombinant Human Hexokinase-4
HK-1 人己糖激酶-1 PKA-226 Recombinant Human Hexokinase-1
HK-2 人己糖激酶-2 PKA-227 Recombinant Human Hexokinase-2
HK-3 人己糖激酶-3 PKA-229 Recombinant Human Hexokinase-3
IGF-IR 人胰岛素样生长因子-I受体 PKA-237 Recombinant Human Insulin Like Growth Factor-I Receptor
ILK1 人整合连接激酶 PKA-353 Recombinant Human Integrin Linked Kinase
JNK2/SAPK1  PKA-216 Recombinant Human JNK2/SAPK1
JNK2a-1 人Jun氨基末端激酶2-α1 PKA-220 Recombinant Human Jun N-terminal kinase 2, alpha 1
JNK2a-2 人Jun氨基末端激酶2-α2 PKA-314 Recombinant Human Jun N-terminal kinase 2, alpha 2
Ketohexokinase 人已酮糖激酶 PKA-359 Recombinant Human Ketohexokinase
LYVE-1 人淋巴管内皮透明质酸受体1 PKA-252 Recombinant Human Lymphatic Endothelial Hyluronan Receptor-1
LYVE-1 （25-235） 人淋巴管内皮透明质酸受体1 PKA-349 Recombinant Human Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 （25-235）
LYVE-1 Sf9 人淋巴管内皮透明质酸受体1 PKA-250 Recombinant Human Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, Sf9
mLYVE-1 Sf9 小鼠淋巴管内皮透明质酸受体1 PKA-251 Recombinant Mouse Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, Sf9
MEK1 人丝裂原活化激酶1 PKA-256 Recombinant Human Mitogen Activated Kinase Kinase 1
NCK2  PKA-337 Recombinant Human NCK2
NME2 人非转移性细胞2 PKA-363 Recombinant Human Non-Metastatic Cells 2
p16-INK4a 人类细胞周期蛋白依赖激酶抑制剂2A PKA-341 Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A
p38a/SAPK2a  PKA-217 Recombinant Human p38 alpha/SAPK2 alpha
PAK4 人p21活化激酶4 PKA-259 Recombinant Human p21 Activated Kinase 4
bP85a 牛磷酸肌醇3激酶A PKA-328 Recombinant bovine Phosphoinositide 3-kinase a, regulatory subunit
bPI3Ka  PKA-327 Recombinant bovine  Phosphoinositide 3-kinase alpha p110a/p85a
PDK1 人丙酮酸脱氢酶激酶同工酶1 PKA-263 Recombinant Human Pyruvate Dehydrogenase Kinase Isozyme 1
PFKM 人磷酸果糖激酶 PKA-365 Recombinant Human Phosphofructokinase, Muscle
PGK1 人磷酸甘油酸激酶1 PKA-351 Recombinant Human Phosphoglycerate Kinase 1
PI3Kb  PKA-333 Recombinant Human  Phosphoinositide 3-kinase beta P110β/p85a
PI3KdGST   PKA-330 Recombinant Human  Phosphoinositide 3-kinase p110d/p85a
PI3KgHis  PKA-329 Recombinant Human  Phosphoinositide 3-kinase p110g
PI3KγD946GST  PKA-331 Recombinant Human  Phosphoinositide 3-kinase p110g inactive mutant
PKACa2/RIa2  PKA-203 Recombinant Protein Kinase A Inactive holoenzyme type 1 alpha
PKACa2/RIIa2  PKA-205 Recombinant Protein Kinase A Inactive holoenzyme type 2 alpha
PKAkt1/PKBa  PKA-206 Recombinant Human Protein Kinase Akt1/PKB alpha Active Enzyme
PKAkt1/PKBa  PKA-207 Recombinant Human Protein Kinase Akt1/PKB alpha Inactive Enzyme
PKAr-1a  PKA-204 Recombinant c-AMP dependant Protein Kinase A regulatory subunit 2 alpha
PKC-a 人蛋白激酶C-α PKA-218 Recombinant Human Protein Kinase C alpha
PKC-b1 人蛋白激酶C-b1 PKA-318 Recombinant Human Protein Kinase C beta 1
PKC-b2 人蛋白激酶C-b2 PKA-319 Recombinant Human Protein Kinase C beta 2
PKC-d 人蛋白激酶C-d PKA-321 Recombinant Human Protein Kinase C delta
PKC-e 人蛋白激酶C-e PKA-322 Recombinant Human Protein Kinase C e
PKC-g 人蛋白激酶C-g PKA-320 Recombinant Human Protein Kinase C gamma
PKC-q 人蛋白激酶C-q PKA-324 Recombinant Human Protein Kinase C q
PKM2 人肿瘤型M2丙酮酸激酶 PKA-339 Recombinant Human Tumour Type M2 Pyruvate Kinase
PPARG 人过氧化物酶体增殖物激活受体γ PKA-228 Recombinant Human Peroxisome Proliferator Activated Receptor Gamma
PPARG （1-477） 人过氧化物酶体增殖物激活受体γ PKA-334 Recombinant Human Peroxisome Proliferator Activated Receptor Gamma （1-477）
PPM1A 人类蛋白磷酸酶亚型1A-α PKA-222 Recombinant Human Protein Phosphatase 1A Alpha Isoform
PRKA1RA  PKA-201 Recombinant c-AMP dependant Protein Kinase A regulatory subunit-1 alpha
PRKACA  PKA-200 Recombinant c-AMP dependant Protein Kinase A catalytic subunit alpha
PRPS1  PKA-361 Recombinant Human Phosphoribosyl Pyrophosphate Synthetase 1
PSPH  PKA-224 Recombinant Human Phosphoserine Phosphatase
PTPN1  PKA-219 Recombinant Human Protein Tyrosine Phosphatase Non Receptor Type-1
PTPN6  PKA-221 Recombinant Human Protein Tyrosine Phosphatase Non Receptor Type-6
SKP1  PKA-356 Recombinant Human S-phase Kinase-Associated Protein 1 Isoform A
STAT1 人信号传导子及转录激活子1 PKA-315 Recombinant Human STAT1
STAT3 人信号传导子及转录激活子3 PKA-316 Recombinant Human STAT3
TGFBR2  PKA-261 Recombinant Human Transforming Growth Factor Beta Receptor II
TIE-1 Fc  PKA-246 Recombinant Human TIE-1 Fc Chimera
mTIE-1 Fc  PKA-247 Recombinant Mouse TIE-1 Fc Chimera
TIE-2 Fc  PKA-248 Recombinant Human TIE-2 Fc Chimera
mTIE-2 Fc  PKA-249 Recombinant Mouse TIE-2 Fc Chimera
TPMT  PKA-255 Recombinant Human Thiopurine S-methyltransferase
VEGFR2 人血管内皮生长因子受体2 PKA-242 Recombinant Human Vascular Endothelial Growth Factor receptor-2
VEGFR2 Fc 人血管内皮生长因子受体2 PKA-243 Recombinant Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera
YWHAB  PKA-348 Recombinant Human Tyr-3/Trp-5 Monooxygenase Activation Protein, Beta
YWHAE  PKA-253 Recombinant Human Tyr-3/Trp-5 Monooxygenase Activation Protein, Epsilon
YWHAG  PKA-238 Recombinant Human Tyr-3/Trp-5 Monooxygenase Activation Protein, Gamma
YWHAG His  PKA-262 Recombinant Human Tyr-3/Trp-5 Monooxygenase Activation Protein, Gamma His Tag
YWHAH  PKA-347 Recombinant Human Tyr-3/Trp-5 Monooxygenase Activation Protein, ETA
YWHAQ  PKA-254 Recombinant Human Tyr-3/Trp- 5 Monooxygenase Activation Protein, Tau
Stratifin 人分层蛋白 PKA-357 Recombinant Human Tyr-3/Trp- 5 Monooxygenase Activation Protein, Sigma
YWHAZ  PKA-257 Recombinant Human Tyr- 3/Trp-5 Mmonooxygenase Activation protein, Zeta
ZMCK2a 重组玉米酪蛋白激酶2α PKA-210 Recombinant Zea Mays Casein Kinase 2 alpha
CKB 人肌酸激酶 CKI-268 Recombinant Human Creatine Kinase Brain
CKB His 人肌酸激酶 CKI-274 Recombinant Human Creatine Kinase Brain, His Tag
CKMB Type-1 人肌酸激酶同工酶1 CKI-269 Recombinant Human Creatine Kinase MB Isoenzyme Type-1
CKMB Type-2 人肌酸激酶同工酶2 CKI-270 Recombinant Human Creatine Kinase MB Isoenzyme Type-2
CKM 人肌酸激酶MM CKI-273 Human Creatine Kinase Muscle
CKM Type-1 人肌酸激酶同工酶MM-1 CKI-271 Recombinant Human Creatine Kinase Muscle Type-1
CKM Type-3 人肌酸激酶同工酶MM-3 CKI-272 Recombinant Human Creatine Kinase Muscle Type-3