7047-Anti-Bovine HMGB1 Antibody, Clone 1-37.10FH_抗体-北京博蕾德生物科技有限公司手机版

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Anti-HMGB1 Antibodies

HMGB1 （high mobility group box 1 protein）, also known as amphoterin, was recently identified as a late stage lethal mediator of endotoxin, and considered as a pro-inflammatory cytokine. Chondrex provides several monoclonal and polyclonal antibodies against synthetic peptides of HMGB1 and intact bovine HMGB1. These antibodies can be used for detecting HMGB1 by ELISA and western blot, or can be used to study the biological effects of HMGB1 in experiments in vitro and in vivo.

Anti-HMGB1 Monoclonal Antibodies

Product	Cross-Reactivity	Subtype	Quantity	Application	Catalog #
Anti-Bovine HMGB1 Antibody, Clone 1-37.10FH	B H Ms R	Mouse IgG2a	1 mg/ml x 0.1 ml	ELISA WB	7047
Anti-Bovine HMGB1 Antibody, Clone 1-37.10FH, Biotinylated	B H Ms R	Mouse IgG2a	1 mg/ml x 0.1 ml	ELISA WB	70471
Anti-HMGB1 Peptide （166-176） Antibody, Clone 1-1.2.11.P2	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	7037
Anti-HMGB1 Peptide （166-176） Antibody, Clone 1-1.2.11.P2, Biotinylated	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	70371
Anti-HMGB1 Peptide （2-11） Antibody, Clone 1-1.2BP1	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	7032
Anti-HMGB1 Peptide （2-11） Antibody, Clone 1-1.2BP1, Biotinylated	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	70321
Anti-HMGB1 Peptide （2-11） Antibody, Clone 1-2.5AP	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	7033
Anti-HMGB1 Peptide （2-11） Antibody, Clone 1-2.5AP1, Biotinylated	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	70331
Anti-HMGB1 Peptide （2-11） Antibody, Clone 1-3.10EP1	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	7034
Anti-HMGB1 Peptide （2-11） Antibody, Clone 1-3.10EP1, Biotinylated	B H Ms R	Mouse IgG1	1 mg/ml x 0.1 ml	ELISA WB	70341

Anti-HMGB1 Polyclonal Antibodies

Product	Cross-Reactivity	Subtype	Quantity	Application	Catalog #	Price （USD）
Anti-Bovine HMGB1 IgG Antibodies	B H Ms R	Rabbit IgG	1 mg/ml x 0.1 ml	ELISA WB	7028	95.80
Anti-Bovine HMGB1 IgY Antibodies	B H Ms R	Chick IgY	1 mg/ml x 0.1 ml	ELISA WB	7064	95.80
Anti-HMGB1 Peptide （166-176） Antibodies	B H Ms R	Rabbit IgG	1 mg/ml x 0.1 ml	ELISA WB	7030	95.80
Anti-HMGB1 Peptide （2-11） Antibodies	B H Ms R	Rabbit IgG	1 mg/ml x 0.1 ml	ELISA WB	7029	95.80

HMGB1

HMGB1 is released by various types of cells such as macrophages, monocytes, and pituicytes exposed to LPS, and is considered a pro-inflammatory cytokine, which stimulates the release of other cytokines such as TNF-alpha and IL-6 through Toll-like receptor 4 （TLR4）. HMGB1 is considered a lethal mediator in sepsis, but may play important roles in chronic inflammatory diseases.

Specificity of Anti-HMGB1 Antibodies

The reactivity of individual antibodies with native and denatured HMGB1 was tested by ELISA. Since the antibodies react equally with native and denatured HMGB1, species and type specificity of individual antibodies was tested by immunoblot analysis on 12% SDS-PAGE using partially purified HMGB1 and HMGB2 fractions from bovine and porcine thymus, in addition to cell lysates from rat C6, mouse RAW264.7, and human K562 cell lines.

All antibodies listed in the table cross-react to all species of HMGB1. Some polyclonal and monoclonal anti-HMGB1 antibodies （catalog # 7032 and 7033） apparently cross-react with HMGB2 due to the high homology of amino acid sequences between HMGB1 and HMGB2

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