细胞生长动力学生存力测定分析系统-高灵敏型细胞恒温量热代谢测试分析

我们看到别人看不到的东西。我们提供表型反应的测量。针对细胞生物学优化的直接代谢读数可实现更好的检测和药物开发。

• calScreener™
• 实时监控
• 无标签，无添加剂
• 无损，允许进行实验后分析
• 与细胞模型无关-2D，3D，悬浮液，类器官等
• 所有细胞类型-细菌，哺乳动物细胞等
• 即用型无菌塑料生长插件
• 48孔板形式，检测成本低

calScreener™无标记测定法使用生物活性监测直接监测生物系统中的代谢反应。我们开发了di一台专为细胞生物学设计的恒温微量量热仪。基于成熟的科学方法进行的高精度细胞代谢监测。无论样品成分和形态如何，calScreener™均可用于在正确的背景下一次研究所有细胞参数的净效应。与使用基于参数（基因型）检测的大多数其他技术相比，calScreener™是真正的表型（功能性）检测。

典型应用：

Dead or Alive

We provide solutions for rapid effect detection in drug development, exploratory research and in-vitro diagnostics. Direct metabolic monitoring of drug effects on cells and bacteria and ultimately if they live or die.

Microbiology

The calScreener™ allows you to monitor bacterial metabolism in real-time and is used for exploratory research and development of new antibiotics. In-vitro diagnostics focused on antimicrobial susceptibility testing aims to provide a rapid and accurate diagnosis of infections caused by multi-resistant bacteria.

Take control of your microbial culture with continuous visualization of the complete metabolic response to single or combination antibiotic treatment efficacy.

Antimicrobial
Susceptibility Testing

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Biofilm-forming
Bacteria

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Antibiotics
Development

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LEARN ABOUT SYMCEL’S HORIZON 2020 PROJECT ON AST AND ANTIMICROBIAL COMBINATION TESTING

Metabolic Research

The calScreener™ assay is employed to directly measure stimulation or inhibition of energy expenditure and cell growth stimulation in metabolic research and drug development settings, both in 2-Dimensional and 3-Dimensional samples as well as in intact tissue biopsies.

Directly measure thermogenesis upon stimulation of brown tissue or energy expenditure in glucose uptake and insulin sensitivity for diabetes research as classic examples.

Brown Adipose Tissue Thermogenesis

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Drug Discovery & Development

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Anti-cancer drug development and oncology research

Improved oncology-targeting monoclonal antibody and small molecule drug development. The calScreener™ assay is used to directly measure the cell-killing effects of potentially apoptotic antibodies or compounds. The potency and mechanism of action are directly monitored providing a true evaluation of cell survival and cell death kinetics.

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Additional applications

Our analytical instrument can be used for monitoring changes in biological processes caused by physical, chemical or biological stimuli in all cell types. Changes in metabolic activity will cause changes in heat dissipated from the cell, tissue or organism. Depending on the biological process involved different kinetic behaviors are anticipated.

This universal approach makes the technology extremely versatile and not limited to one specific type of assay or question. The calScreener technology has been tested in use for a broad range of applications in addition to microbiology, metabolism and oncology. Follow the link in the title above for a brief summary on some of these and please do reach out for discussions on whatever application may be on your mind.