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康宁 88-591-CM无血清细胞培养基 买五送一
面议康宁CORNING Matrigel 基质胶 现货折扣
面议356234 corning Matrigel基质胶 康宁代理
面议Takara GT-T551H3 淋巴细胞无血清培养基H3
面议C3620-0500 VivaCell 羊水细胞培养基 现货
面议VivaCell羊水细胞培养基AmoioType-1 Medium
面议VivaCell C3620-0100 Bio-AMF-2 培养基
面议LL-0023 Lifeline代理 气道上皮细胞培养基
面议Lifeline LL-0023 气道上皮细胞培养基 现货
面议Lifeline LL-0023 气道上皮细胞培养基套装
面议Lifeline代理 气道上皮细胞培养套装 现货
面议lifeline LL-0003 VEGF内皮细胞培养基供应
面议产品英文名称: IWP-2
产品中文名称: IWP-2
IWP-2 产品英文简述:
IWP-2:N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM (Ref.). Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.
Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 (2009)
Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.
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