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TAKARA授权代理 Cellartis MSC培养基 现货
面议TAKARA代理 Cellartis MSC培养基 Xeno-Free
面议TAKARA MSC Xeno-Free间充质干细胞培养基
面议华雅干细胞 CCGmHuM间充质培养基 现货
面议HY Stemcell CCGmHuM间充质干细胞培养基
面议康宁授权代理 新品 淋巴细胞无血清培养基
面议康宁 88-591-CM 淋巴细胞培养基 现货供应
面议康宁代理 88-591-CM 淋巴细胞无血清培养基
面议88-591-CM 康宁 淋巴细胞无血清培养基591
面议Corning® 淋巴细胞无血清培养基591 现货
面议Corning® 淋巴细胞无血清培养基591
面议MSC 间充质干细胞培养补充剂 05-201-1U
面议产品英文名称: IWP-2
产品中文名称: IWP-2
IWP-2 产品英文简述:
IWP-2:N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM (Ref.). Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.
Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 (2009)
Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.
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