cobioer/科佰生物 品牌
代理商厂商性质
南京市所在地
hEpCAM/4T1
I. Background | |||
EpCAM(Epithelial Cell Adhesion Molecule,上皮细胞粘附分子,CD326)是一种跨膜 糖蛋白,在细胞的信号传导、粘附、细胞增殖分化、器官形成和维持中起着重要作用。 EpCAM 基因在人胚胎期除了胸腺组织以外的几乎所有的上皮组织中表达。在正常成人组 织中,EpCAM 在胃肠道、生殖系统和呼吸道的各种组织中的简单、假复层和移行上皮细 胞的基底外侧面表达。EpCAM 发生功能缺失性突变会导致先天性簇绒性肠病,在病理条 件下,EpCAM 在起源于上皮细胞的癌症中特异性表达。此外,EpCAM 在肺癌、乳腺癌、 宫颈癌和胰腺癌等多种癌症中高表达。 | |||
II. Introduction | |||
Host Cell: | 4T1 | ||
Expressed gene: | hEpCAM | ||
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
Freeze Medium: | 90% FBS+10% DMSO | ||
Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin | ||
Mycoplasma Testing: | Negative | ||
Storage: | Liquid nitrogen | ||
III. Description of Host Cell Line | |||
Organism: | Mouse | ||
Tissue: | Mammary gland | ||
Morphology: | Epithelial | ||
Growth Properties: | Adherent | ||
IV. Representative Data | |||
Figure 1. Recombinant hEpCAM/4T1 stably expressing hEpCAM. | |||