Charybdotoxin /ChTx

K_Ca²⁺ channel blocker(KCa2+ 通道阻断剂)

Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca²⁺ activated K⁺ channels K_Ca1.1 in nanomolar concentrations (IC₅₀~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocksK_Ca3.1 (IC₅₀ 5 nM), K_v1.2 (IC₅₀ 14 nM), K_v1.3 (IC₅₀ 2.6 nM) and K_v1.6 (IC₅₀ 2 nM) channels.

ChTx技术资料

氨基酸序列：

H-Pyr-Phe-Thr-Asn-Val-Ser-Cys⁷-Thr-Thr-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys²⁸-Met-Asn-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Ser-OH 

二硫键：Disulfide bonds between Cys⁷-Cys²⁸, Cys¹³-Cys³³, and Cys¹⁷-Cys³⁵

长度（aa）： 37 

分子式：C₁₇₆H₂₇₇N₅₇O₅₅S₇ 

分子量： 4295.90 Da 

外观：White lyophilized solid 

可溶性： water and saline buffer 

CAS 号：95751-30-7 

来源：Synthetic 

纯度：> 97%

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