OD1

OD1, a potent Nav1.7 channel activator

OD1，有效的Nav1.7通道激活剂

OD1 is a scorpion peptide that has been isolated initially from the venom of the scorpion Odonthobuthus doriae. OD1 potently inhibits fast inactivation of mammalian channels Na_v1.7 (EC50 4.5 nM), Na_v1.4 (EC₅₀ 10 ± 2 nM) and Na_v1.6 (EC₅₀ 47 ± 10 nM). OD1 also blocks fast inactivation of the para/tipE insect channel (EC₅₀ 80 nM). OD1 weakly affects mammalian Na_v1.3 and Na_v1.5 (EC₅₀ > 1 μM) and does not affect Na_v1.2 and Na_v1.8. OD1 induces spontaneous pain when injected in animal in association with our without Veratridine and can be used to test the analgesic effects of Na_v1.7 blockers in-vivo.

OD1技术资料

氨基酸序列：

GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRIPGKCR-NH₂

二硫键：C13-C64 ; C17-C37 ; C23-C47 ; C27-C49 

长度 (aa)： 65

分子式： C₃₀₈H₄₆₆N₉₀O₉₅S₈

分子量：7206.20 Da

外观：White lyophilized solid

可溶性： Water or saline buffer, 5 mg/mL maximum (recommendation)

Counterion: TFA salts

CAS 号：not available 

来源：Synthetic

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