AdTx1 (rho-Da1a – ρ-Da1b)

Selective antagonist of the alpha(1A)-adrenoceptor

肾上腺受体alpha(1A)选择性拮抗剂

AdTx1 (rho-Da1a – ρ-Da1b) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1is a potent relaxant of smooth muscles.

AdTx1 (rho-Da1a – ρ-Da1b)技术资料

氨基酸序列：

LTC³VTSKSIFGITTEDC¹⁷PDGQNLC²⁴FKRRHYVVPKIYDSTRGC⁴²AATC⁴⁶PIPENYDSIHC⁵⁷C⁵⁸KTDKC⁶³NE

二硫键： Cys³-Cys²⁴, Cys¹⁷-Cys⁴², Cys⁴⁶-Cys⁵⁷, Cys⁵⁸-Cys⁶³

长度 (aa)： 65

分子式：C₃₁₀H₄₈₁N₈₇O₁₀₀S₈

分子量（平均）：7283.29 Da

外观：White lyophilized solid

可溶性：water and saline buffer

CAS 号：not available

来源：Synthetic

纯度：> 98%

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