HsTx-1  

Selective blocker of K_v1.3 channel(钾离子通道K_v1.3选择性阻断剂)

HsTx-1 is a member of the a-KTx6 family of scorpion toxins active on voltage-gated K_v1.3 channels (K_d close to 10 pM).  is also very active on K_v1.2 channels (Kd around 7 nM). It is however inactive on apamin-sensitive SK channels. It is one of the most potent toxins active on K_v1.3 channel.

技术资料

氨基酸序列：

Ala-Ser-Cys³-Arg-Thr-Pro-Lys-Asp-Cys⁹-Ala-Asp-Pro-Cys¹³-Arg-Lys-Glu-Thr-Gly-Cys¹⁹-Pro-Tyr-Gly-Lys-Cys²⁴-Met-Asn-Arg-Lys-Cys²⁹-Lys-Cys³¹-Asn-Arg-Cys³⁴-NH₂ 

二硫键： Cys³-Cys²⁴, Cys⁹-Cys²⁹, Cys¹³-Cys³¹ and Cys¹⁹-Cys³⁴ 

长度 (aa)：34 

分子式： C₁₄₉H₂₄₆N₅₄O₄₆S₉ 

分子量：3819.87 Da 

外观：White lyophilized solid 

可溶性： water and saline buffer 

CAS 号：not available 

来源： Synthetic  

纯度： > 95 %

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