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softwell(柔软、有弹性)细胞培养器皿
面议干细胞因子微球(StemBeads)
面议Bicolor’s Purple-Jelley Assay(透明质酸检测试剂盒)
面议Aurion 胶体金溶液(Gold Sols)
面议LudgerTag V-tag 糖肽标记和释放试剂盒
面议免疫球蛋白IgG糖基化检测/分析试剂盒——Ludger品牌
面议抗体糖基化检测/分析试剂盒——Ludger品牌
面议单克隆抗体(单抗)糖基化检测/分析试剂盒-Ludger品牌
面议弹性150mm培养皿Petrisoft-150mm dish-Non Activated-xx pK
面议弹性100mm培养皿Petrisoft-100mm dish-Non Activated-xx pK
面议弹性35mm培养皿Petrisoft-35mm dish-Non Activated-xx pKa
面议弹性150mm培养皿Petrisoft-150mm dish-Collagen I-xx pKa
面议
Mambalgin-1 was initially isolated by Sylvie Diochot and collaborators from the venom of the black mamba (Dendroaspis polylepis polylepis). is a potent and selective blocker of acid-sensing ion channels (ASIC). ASIC channels have been demonstrated to be implied in pain pathways and appear to be promising therapeutic targets. rapidly and reversibly inhibits recombinant homomeric ASIC1a (IC50=55 nM) and heteromeric ASIC1a+ASIC2a (IC50=246 nM) or ASIC1a+ASIC2b channels (IC50=61 nM) but also human channels hASIC1b (IC50=192 nM) and hASIC1a+hASIC1b (IC50=72nM).
belongs to the family of three-finger toxins and has no sequence/structural homology with either PcTx1 or APETx2. differs from mambalgin-2 by one amino acid. Both have demonstrated a similar activity. has no effect on ASIC2a, ASIC3, ASIC1a+ASIC3 and ASIC1b+ASIC3 channels, as well as on TRPV1, P2X2, 5-HT3A, Nav1.8, Cav3.2 and Kv1.2 channels.
Fig 1: Dose-response curve of the effect of synthetic #MAM001 on ASIC1a current recorded in Xenopus oocytes. In this system, an IC50 of 21 nM was determined.
氨基酸序列:
LKC3YQHGKVVTC12HRDMKFC19YHNTGMPFRNLKLILQGC37SSSC41SETENNKC49C50STDRC55NK-OH
二硫键:Cys3-Cys19, Cys12-Cys37, Cys41-Cys49, Cys50-Cys55
长度 (aa): 57
分子式: C272H429N85O84S10
分子量:6554.59 Da
外观:White lyophilized solid
可溶性:water or saline buffer
CAS 号:not available
来源:Synthetic
纯度:> 98%
产品信息
货号 | 名称 | 规格 |
MAM001-50010 | 50ug/100ug/5×10ug |
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