丝氨酸/苏氨酸蛋白激酶38抗体

英文名称 STK38
中文名称 丝氨酸/苏氨酸蛋白激酶38抗体
别    名 NDR 1; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; Serine/threonine protein kinase 38; STK 38; STK-38; STK38_HUMAN.

说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  细胞生物  免疫学  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human STK38
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38.

Function:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2.

Subunit:
Homodimeric S100B binds two molecules of STK38.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.xy-3357R    PYK2富含脯氨酸的酪氨酸激酶2抗体
xy-3400R    phospho-PYK2 (Tyr402)磷酸化富含脯氨酸的酪氨酸激酶2抗体
xy-3401R    phospho-PYK2 (Tyr881)磷酸化富含脯氨酸的酪氨酸激酶2抗体
xy-3362R    Phospho-p90RSK (Ser380)磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体
xy-3363R    Phospho-p90RSK (Thr359 + Ser363)磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体
xy-3364R    Phospho-p90RSK (Thr573)磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体
xy-1828R    Plasminogen纤维蛋白溶酶原抗体
xy-1995R    p95 NBS1DNA修复蛋白NBS1抗体
xy-2512R    PRMT1蛋白质精氨酸甲基转移酶1抗体
xy-2589R    P450 1A2/CYP1A2细胞色素P450 1A2抗体
xy-3460R    Phospho-PLC gamma 1 (Tyr771)磷酸化磷酯酶Cγ1抗体
xy-3342R    Phospho-PLC gamma 1(Ser1248)磷酸化磷酯酶Cγ1抗体
xy-3343R    Phospho-PLC γ1 (Tyr783)磷酸化磷酯酶Cγ1抗体
xy-3345R    Phospho-PLK1 (Ser137)磷酸化丝/苏氨酸蛋白激酶Plk1抗体
xy-3355R    Phospho-PNK1 (Ser114 + Thr118)磷酸化多聚合苷酸激酶3磷酸化酶抗体
xy-3538R    PSD93突触后密度蛋白93抗体
xy-3348R    Phospho-PSD93 (Tyr340)磷酸化突触后密度蛋白93抗体
xy-3349R    Phospho-PSD95 (Tyr236 + Tyr240)磷酸化突触后密度蛋白95抗体
xy-3350R    Phospho-PTEN(Ser380)磷酸化肿瘤抑制基因PTEN抗体
xy-3351R    Phospho-PTEN(Ser380 + Thr382 + Thr383)磷酸化肿瘤抑制基因PTEN抗体
xy-3539R    Paxillin桩蛋白Paxillin抗体
xy-3352R    Phospho-Paxillin (Tyr118)磷酸化桩蛋白Paxillin抗体
xy-3540R    PIM1丝氨酸/苏氨酸激酶蛋白Pim1抗体
xy-3353R    Phospho-PIM1(Tyr218)磷酸化前病毒整合位点蛋白1抗体
xy-3541R    Pin1肽基脯氨酞顺反异构酶Pinl抗体
xy-3354R    Phospho-Pin1 (Ser16)磷酸化肽基脯氨酞顺反异构酶Pinl抗体
xy-3356R    Phospho-Progesterone Receptor(Ser190)磷酸化孕激素受体抗体
xy-6417R    phospho-PI3 Kinase p110 beta(Ser1070)磷酸化磷脂酰肌醇激酶（PI3Kβ）抗体
xy-6418R    phospho-PP2A alpha (Tyr307)磷酸化蛋白磷酸酶2A（PP2Aα）抗体
xy-7918R    PLK5丝氨酸/苏氨酸蛋白激酶5抗体