Anti-Human CD3 SAFIRE Purified CD3单抗

产品英文名称：Anti-Human CD3 SAFIRE Purified

产品中文名称：CD3单克隆抗体（OKT3）/抗人CD3抗体

BioGems CD3单抗特点

极低的内毒素含量，低于0.01EU/μg蛋白 

不含叠氮钠，适用于体内或体外实验

高蛋白纯度

应用

BioGems CD3单抗适用细胞：NK和NKT细胞，T细胞，Treg细胞，Th17细胞

作用机理

OKT3单克隆抗体特异性地与CD3的ε链/T淋巴细胞抗原受体复合物发生反应。CD3的复合物包括 γ、 δ和ε链，它是TCR复合物的一部分，由成熟的T淋巴细胞和胸腺细胞谱系表达。CD3通过信号转导增强抗原识别。而OKT3抗体是一种免疫抑制剂，在肝脏、心脏和肾脏同种异体移植排斥方面，这已被证明是一种有效的治疗剂。

Description

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

质量控制

BioGems CD3单克隆抗体经过亲和层析纯化。

内毒素水平：蛋白质小于0.01 EU/µg，鲎试剂法检测。

订购信息  

红荣微再代理的BioGems CD3/CD28单抗正进行年末*活动：买二送一（四折之后），并赠送抗霾礼盒

Biogems是Peprotech的抗体品牌。CD3/CD28单抗BioGems*现正进行4折*。

CD3  500ug 现价4130元 *(4折) 1652元

CD28  500ug 现价3640元 *(4折) 1456元

BioGems的SAFIRE (Sodium Azide Free Immensely Reduced Endotoxins) 类产品是BioGems品牌下的功能性抗体产品，经特殊工艺生产、纯化，具有诸多特点，可用于免疫细胞功能的激活、阻断、中和研究，是肿瘤免疫研究的重要工具。

SAFIRE纯化CD3单抗 (clone: OKT3)可以与TCR复合物结合，激活T细胞；SAFIRE纯化CD28单抗 (clone: CD28.2)是 T细胞激活、增殖的辅助刺激分子。

红荣微再*

CD3 CD28单抗买二送一！

在4折基础上再加优惠。

买二：CD3、CD28任选两支。

送一：CD3、CD28任选一支。

赠送抗霾礼盒

抗霾礼盒

易可滤挂机空调伴侣防PM2.5空调过滤

易可滤防雾霾过滤PM2.5可更换式口罩

价值600多元

活动时间：2017年12月15日 - 2018年3月31日

欢迎您致电 华雅再生医学旗舰公司：红荣微再（上海）生物工程技术有限公司  ：1500 1904 520。红荣微再-客服:  经销商专员

CD3单克隆抗体（OKT3）/抗人CD3抗体免疫细胞治疗介绍：

CD3单克隆抗体（OKT3）/抗人CD3抗体是由肽链以非共价键组成的复合分子，在成熟T细胞表面表达，对阻断急性同种异体排斥反应起主要作用。 CD3分子与TCR组成复合受体分子，激活酪氨酸激酶，促使CD3分子免疫受体酪氨酸活化基序中的酪氨酸（Y）磷酸化。磷酸化的酪氨酸（pY）进一步磷酸 化下游含酪氨酸的蛋白，从而引起激酶活化的级联反应，调控T细胞增殖和活化的靶基因，引起基因的表达和转录，T细胞由静止状态转为增殖和活化状态。

CD3分子具有稳定TCR结构和传递活化信号的作用。针对CD3分子的单克隆抗体能够激发或阻断T细胞活化信号转导，清除效应T细胞或诱导调节T细胞的产生。

说明书

Product Information

Clone: OKT3

Format/Conjugate: SAFIRE Purified

Concentration: 2 mg/mL

Reactivity: Human

Isotype: Mouse IgG2a, kappa

Formulation: Phosphate-buffered aqueous solution, ph7.2.

Applications: FC, FA, IHC

Research Interest: Adaptive Immunity

Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells

Preparation & Storage:The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Application Notes

The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic procedures

Catalog Number : 05121-25

Description

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

Additional Information

Clone OKT3

Format:SAFIRE Purified

Applications FC, FA, IHC

Reactivity Human

Isotype:Mouse IgG2a, kappa

Research Interest: Adaptive Immunity

Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.

欢迎您致电 华雅再生医学旗舰公司：红荣微再（上海）生物工程技术有限公司  ：1500 1904 520。红荣微再-客服:  经销商专员