144625-HRP Rabbit Anti-EIF2AK4抗体说明

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uSBIo品牌144625-HRP Rabbit Anti-EIF2AK4抗体实验说明

144625-HRP

144625-HRP Rabbit Anti-EIF2AK4 (GCN2, KIAA1338, GCN2-like protein, Eukaryotic translation initiation factor 2-alpha kinase 4) (HRP)

EIF2AK4（真核翻译起始因子2-Alpha激酶4），也称为GCN2，是人类中由EIF2AK4基因编码的酶。 EIF2AK4属于激酶家族，其磷酸化真核翻译起始因子-2的α亚基以响应不同的细胞应激下调蛋白质合成。 Hartz（2005）基于EIF2AK4序列与基因组序列的比对将EIF2AK4基因定位于染色体15q15.1。 Berlanga等。 （1999）证明从小鼠肝脏提取物免疫纯化的Gcn2可以在体外磷酸化兔Eif2。在用小鼠Eif2ak4转染的人胚肾细胞中，血清饥饿使磷酸化EIF2-α的水平增加超过2倍。 Costa-Mattioli等。 （2005）报道了来自Gcn2缺失小鼠的海马切片的*特征：在CA1中，单个100-Hz训练诱导强烈且持续的长期增强（晚期LTP或L-LTP），其依赖于转录和翻译。 

144625-HRP Rabbit Anti-EIF2AK4抗体说明

EIF2AK4 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4), also called GCN2, is an enzyme that in humans is encoded by the EIF2AK4 gene. EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. Hartz (2005) mapped the EIF2AK4 gene to chromosome 15q15.1 based on an alignment of the EIF2AK4 sequence with the genomic sequence. Berlanga et al. (1999) demonstrated that Gcn2 immunopurified from mouse liver extracts could phosphorylate rabbit Eif2 in vitro. Serum starvation increased the level of phosphorylated EIF2-alpha more than 2-fold in human embryonic kidney cells transfected with mouse Eif2ak4. Costa-Mattioli et al. (2005) reported a unique feature of hippocampal slices from Gcn2-null mice: in CA1, a single 100-Hz train induced a strong and sustained long-term potentiation (late LTP or L-LTP), which was dependent on transcription and translation.

Applications

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilutions

Western Blot: 0.1-0.5ug/ml. The detection limit for EIF2AK4 is ~0.5ng/lane under reducing conditions. Optimal dilutions to be determined by the researcher.

Storage and StABIlity

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Note: Applications are based on unconjugated antibody.

Immunogen

Synthetic peptide corresponding aa870-888, ATDHLAFSADSKQDDQTGD in the middle region of human EIF2AK4 (Q9P2K8)

Form

Supplied as a liquid in PBS, pH 7.2. Labeled with horserADIsh peroxidase (HRP).

Purity

Purified by immunoaffinity chromatography.

Specificity

Recognizes human h.EIF2AK4. No crossreactivity with other proteins.

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