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传统动物心电图测量分析采用体表方式,虽操作简单,但是存在测量位置影响大、测量精度不高等局限性,而心外膜表面电极测量心电图操作极为复杂且创伤性大,实验中较少采用。为解决这一难题,Scisence 提供微创的多电极电生理导管,设计使研究者能够对生物电在整个心脏的扩散过程进行更为深入的测量和分析。
电生理导管系统由八电极电生理导管、电极分配盒及第三方生物电放大器及刺激器组成。
工作原理:八电极电生理导管上的每对电极均独立受控于电极分配盒,电极分配盒通过 2mm 针式连接线与第三方生物电放大器或刺激器相连,通过采集对应的电极对引导的电信号数据。八电极电生理导管可用于心脏起搏,电信号记录,进而用于心脏电生理的各方面研究。
电生理导管工作原理图
心脏电生理导管需要插入大鼠、小鼠等动物的心脏内部,测量和纪录心房及心室的电生理信号:传导时间、不应期、希氏束电位、窦房结和房室结功能、心律失常的诱导。
LabScribe 心电分析模块
5. 可轻松提取源数据或平均数据作为图片或文本导出;
6. 可选 ASCII 文本导入模块将其他第三方设备采集的 ECG 数据导入本软件进行分析;
LabScribe 进行心电分析
相关文献:
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5. Iwasaki YK, et. al. “Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea.” Heart Rhythm. 2012 Sep; 9(9): 1409-16.e1
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8. Benito B, et. al. “Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training.” Circulation. 2011 Jan 4; 123(1): 13-22
9. Prestia KA, et al. “Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice.” Front Physiol. 2011 Jan 31; 2(1): 1-7
10. Aubin MC, et al. “A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia.” J Appl Physiol. 2010 Feb; 108: 933-940
11. Lu Y, et al. “MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation.” Circulation. 2010 Dec; 122(23): 2378-87
12. Mathur N, et al. “Sudden infant death syndrome in mice with an inherited mutation in RyR2.” Circ Arrhythm Electrophysiol. 2009 Dec; 2: 677-685
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