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2019/6/27 9:28:09 鞘脂是一类含有鞘氨醇骨架的两性脂,是仅次于磷脂的第二大类膜脂。鞘脂一端连接着一个长链的脂肪酸,另一端为一个极性的醇。鞘脂正常代谢的维持不仅是细胞生存的关键,也对包括抗病免疫调控、植物育性等在内的发育过程,有着十分重要的作用。丝氨酸棕榈酰转移酶(Serine palmitoyltransferase, SPT)是催化鞘脂合成的步,同时也是关键的限速步骤。在人和酵母中,类黏膜蛋白(Orosomucoid, ORM)通过负调控SPT酶来维持细胞内的鞘脂稳态。稳定的同位素标准可以很容易地检测到质谱,同时相比天然鞘脂显示出几乎相同的物理性质,这对于确保分析物和内部标准物之间具有相似的提取特性和信号响应非常重要。
鞘脂包括鞘磷脂、脑苷脂以及神经节苷脂,一般存在于植物和动物膜内,尤其是在中枢神经系统的组织内含量丰富。又称鞘磷脂、鞘氨醇磷脂或神经磷脂·由鞘氨醇、脂肪酸与磷酰胆碱组成的分子,它是鞘磷脂类的典型代表,在高等动物的组织中含量极为丰富。鞘脂作为信号分子在植物生长和胁迫过程中扮演着重要的角色。
With the availability of stable isotope standards and the incorporation of soft ionization techniques in mass spectrometry the detection of very small amounts of sphingolipids can be accomplished. The two major approaches of sphingolipidomic studies are the liquid chromatography-mass spectrometry based methods and the shotgun lipidomics approach.These techniques require the use of internal standards for each class of sphingolipid expected to be found in a sample. Stable isotope standards can be easily detected by mass spectrometry while demonstrating nearly identical physical properties as compared to natural sphingolipids. This is very important to ensure similar extraction properties and signal response between the analytes and the internal standards.
D-erythro-Sphingosine, D9 1 mg
Synonym:15,15,16,16,17,17,18,18,18-D9-2-Amino-octadec-4-ene-1,3-diol;
N-omega-CD3-Octadecanoyl-D-erythro-sphingosine 1 mg
N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9 1 mg
N-omega-CD3-Octadecanoyl-D-erythro-dihydrosphingosine 1 mg
N-1-13C-Hexadecanoyl-D-erythro-sphingosylphosphorylcholine 1mg
N-Octadecanoyl-D3-D-erythro-sphingosine-1-phosphate, deuterated 1 mg $
N-Octadecanoyl-D35-psychosine, (perdeuterated, C18:0 fatty acid) 5 mg
N-omega-CD3-Hexadecanoyl-glucopsychosine 1 mg
N-omega-CD3-Octadecanoyl-sulfatide 1 mg
N-omega-CD3-Hexadecanoyl-lactosylceramide 1 mg
N-omega-CD3-Octadecanoyl-ceramide trihexoside 500 µg
N-omega-CD3-Octadecanoyl monosialoganglioside GM1 (NH4+ salt) 500 µg
N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt) 250 ug
N-omega-CD3-Octadecanoyl monosialoganglioside GM3 (NH4+ salt) 250 ug
N-omega-CD3-Octadecanoyl disialoganglioside GD3 500 µg
342021 | 71012-19-6 | 神经节四酰基鞘氨醇 Gangliotetraosylceramide |
342020 | 神经三已糖基神经酰胺 Gangliotriosylceramide | |
342019 | 71812-11-8 | 岩藻糖单唾液酸神经节苷酯 Fucosylated monosialoganglioside GM1;Fucosyl-GM1 |
342018 | 62010-37-1 | 双唾液酸神经节苷脂GD3,Disialoganglioside GD3 (NH4+salt);GD3 |
342017 | 65988-71-8 | 双唾液酸神经节苷脂GD2,Disialoganglioside GD2 (NH4+salt);GD2 |
342016 | 19553-76-5 | 双唾液酸神经节苷脂GD1b,Disialoganglioside GD1b (NH4+salt);GD1b |
342015 | 12707-58-3 | 双唾液酸神经节苷脂GD1a,Disialoganglioside GD1a (NH4+salt);GD1a |
342014 | 171483-40-2 | 溶菌酶-单唾液酸神经节苷酯 lyso-Monosialoganglioside GM1 (NH4+salt);lyso-GM1 |
342012 | 6036-75-5 | L-反赤藓式-鞘鞍醇 L-erythro-Sphingosine |
342011 | N-棕榈酰-乳糖神经酰胺 N-Hexadecanoyl-lactosylceramide | |
342010 | 4682-48-8 | 乳糖神经酰胺 Lactosylceramides |
342009 | N-Hexadecanoyl-D3-lactosylceramide, deuterated | |
342008 | 4682-48-8 | 乳糖神经酰胺 Lactosylceramides |
342007 | 4682-48-8 | 乳酰基-N-脂酰基鞘氨醇 Lactosylceramides |
342006 | 溶血乳糖苷神经酰胺 lyso-Lactosylceramide | |
342005 | N-C16:0-Cyclopropenylceramide | |
342004 | N-C16:0-Cyclopropenylceramide | |
342003 | 2-氟棕榈酸甲酯,Methyl 2-fluoropalmitate | |
342002 | 85496-63-5 | 硫酸脑苷脂 Cerbroeside sulfate ;Sulfatides |
342001 | 6036-85-7 | D-苏式-鞘鞍醇 D-threo-Sphingosine |
342000 | 2238-90-6 | 神经鞘氨醇半乳糖苷 Psychosine |
341996 | 鞘氨醇半乳糖苷 N-Octadecanoyl-D35-psychosine, perdeuterated | |
341995 | N-二十四酰-硫脑苷脂 N-Tetracosanoyl sulfatide | |
341994 | N-Acetyl-sulfatide | |
341993 | N-十五酰基神经鞘氨醇半乳糖苷 N-Pentadecanoyl-psychosine | |
341992 | N-Octanoyl-beta-D-galactosylceramide | |
341991 | N-Octadecanoyl-D3-sulfatide, deuterated | |
341990 | N-辛酰基-beta-D-半乳糖酰基鞘氨醇 N-Octanoyl-beta-D-galactosylceramide | |
341989 | N-Hexadecanoyl-sulfatide | |
341988 | N-C16:0-D3-葡萄糖神经酰胺 N-Hexadecanoyl-D3-glucopsychosine, deuterated | |
341987 | 38621-58-8 | lyso-Sulfatide (NH4+salt) |
341986 | N-乙酰神经鞘氨醇半乳糖苷 N-Acetyl-psychosine | |
341985 | 52050-17-6 | Glucopsychosine |
341984 | 52050-17-6 | 葡萄糖神经酰胺 Glucopsychosine |
341982 | 葡萄糖脑苷脂 Glucocerebrosides | |
341981 | 94885-04-8 | N-Hexanoyl-NBD-sphingosylphosphorylcholine (mixture of D-erythro and L-threo isomers) |
341979 | 葡萄糖脑苷脂 Glucocerebrosides | |
341978 | 葡萄糖脑苷脂标准品 Glucocerebrosides | |
341977 | 536-13-0 | 半乳糖神经酰胺 Cerebrosides; Kerasin (top spot) |
341976 | 37211-11-3 | 脑苷脂 Cerebrosides; Phrenosin (bottom spot) |
341975 | 葡萄糖神经酰胺 Glucocerebrosides,Plant | |
341974 | 85305-88-0 | 半乳糖苷神经酰胺 Galactosylceramide (Galactocerebroside) |
341973 | 127593-21-9 | Methyl 3-hydroxyundecanoate |
341972 | Methyl 3-hydroxytridecanoate | |
341971 | 94885-04-8 | 荧光鞘磷脂 N-Hexanoyl-NBD-sphingosylphosphorylcholine |
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