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鞘磷脂、脑苷脂以及神经节苷脂系列同位素标记简介

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2019/6/27 9:28:09

鞘磷脂、脑苷脂以及神经节苷脂系列同位素标记简介

    鞘脂是一类含有鞘氨醇骨架的两性脂,是仅次于磷脂的第二大类膜脂。鞘脂一端连接着一个长链的脂肪酸,另一端为一个极性的醇。鞘脂正常代谢的维持不仅是细胞生存的关键,也对包括抗病免疫调控、植物育性等在内的发育过程,有着十分重要的作用。丝氨酸棕榈酰转移酶(Serine palmitoyltransferase, SPT)是催化鞘脂合成的步,同时也是关键的限速步骤。在人和酵母中,类黏膜蛋白(Orosomucoid, ORM)通过负调控SPT酶来维持细胞内的鞘脂稳态。稳定的同位素标准可以很容易地检测到质谱,同时相比天然鞘脂显示出几乎相同的物理性质,这对于确保分析物和内部标准物之间具有相似的提取特性和信号响应非常重要。
    鞘脂包括鞘磷脂、脑苷脂以及神经节苷脂,一般存在于植物和动物膜内,尤其是在中枢神经系统的组织内含量丰富。又称鞘磷脂、鞘氨醇磷脂或神经磷脂·由鞘氨醇、脂肪酸与磷酰胆碱组成的分子,它是鞘磷脂类的典型代表,在高等动物的组织中含量极为丰富。鞘脂作为信号分子在植物生长和胁迫过程中扮演着重要的角色。

     With the availability of stable isotope standards and the incorporation of soft ionization techniques in mass spectrometry the detection of very small amounts of sphingolipids can be accomplished. The two major approaches of sphingolipidomic studies are the liquid chromatography-mass spectrometry based methods and the shotgun lipidomics approach.These techniques require the use of internal standards for each class of sphingolipid expected to be found in a sample. Stable isotope standards can be easily detected by mass spectrometry while demonstrating nearly identical physical properties as compared to natural sphingolipids. This is very important to ensure similar extraction properties and signal response between the analytes and the internal standards.

D-erythro-Sphingosine, D9     1 mg

Synonym:15,15,16,16,17,17,18,18,18-D9-2-Amino-octadec-4-ene-1,3-diol;

N-omega-CD3-Octadecanoyl-D-erythro-sphingosine    1 mg

N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9  1 mg

N-omega-CD3-Octadecanoyl-D-erythro-dihydrosphingosine  1 mg

N-1-13C-Hexadecanoyl-D-erythro-sphingosylphosphorylcholine   1mg

N-Octadecanoyl-D3-D-erythro-sphingosine-1-phosphate, deuterated   1 mg $

N-Octadecanoyl-D35-psychosine, (perdeuterated, C18:0 fatty acid)   5 mg

N-omega-CD3-Hexadecanoyl-glucopsychosine   1 mg

N-omega-CD3-Octadecanoyl-sulfatide   1 mg

N-omega-CD3-Hexadecanoyl-lactosylceramide   1 mg

N-omega-CD3-Octadecanoyl-ceramide trihexoside   500 µg

N-omega-CD3-Octadecanoyl monosialoganglioside GM1 (NH4+ salt)   500 µg

N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt)   250 ug

N-omega-CD3-Octadecanoyl monosialoganglioside GM3 (NH4+ salt)  250 ug

N-omega-CD3-Octadecanoyl disialoganglioside GD3   500 µg

34202171012-19-6神经节四酰基鞘氨醇 Gangliotetraosylceramide
342020 神经三已糖基神经酰胺 Gangliotriosylceramide
34201971812-11-8岩藻糖单唾液酸神经节苷酯 Fucosylated monosialoganglioside GM1;Fucosyl-GM1
34201862010-37-1双唾液酸神经节苷脂GD3,Disialoganglioside GD3 (NH4+salt);GD3
34201765988-71-8双唾液酸神经节苷脂GD2,Disialoganglioside GD2 (NH4+salt);GD2
34201619553-76-5双唾液酸神经节苷脂GD1b,Disialoganglioside GD1b (NH4+salt);GD1b
34201512707-58-3双唾液酸神经节苷脂GD1a,Disialoganglioside GD1a (NH4+salt);GD1a
342014171483-40-2溶菌酶-单唾液酸神经节苷酯 lyso-Monosialoganglioside GM1 (NH4+salt);lyso-GM1
3420126036-75-5L-反赤藓式-鞘鞍醇 L-erythro-Sphingosine
342011 N-棕榈酰-乳糖神经酰胺 N-Hexadecanoyl-lactosylceramide
3420104682-48-8乳糖神经酰胺 Lactosylceramides
342009 N-Hexadecanoyl-D3-lactosylceramide, deuterated
3420084682-48-8乳糖神经酰胺 Lactosylceramides
3420074682-48-8乳酰基-N-脂酰基鞘氨醇 Lactosylceramides
342006 溶血乳糖苷神经酰胺 lyso-Lactosylceramide
342005 N-C16:0-Cyclopropenylceramide
342004 N-C16:0-Cyclopropenylceramide
342003 2-氟棕榈酸甲酯,Methyl 2-fluoropalmitate
34200285496-63-5硫酸脑苷脂 Cerbroeside sulfate ;Sulfatides
3420016036-85-7D-苏式-鞘鞍醇 D-threo-Sphingosine
3420002238-90-6神经鞘氨醇半乳糖苷 Psychosine
341996 鞘氨醇半乳糖苷 N-Octadecanoyl-D35-psychosine, perdeuterated
341995 N-二十四酰-硫脑苷脂 N-Tetracosanoyl sulfatide
341994 N-Acetyl-sulfatide
341993 N-十五酰基神经鞘氨醇半乳糖苷 N-Pentadecanoyl-psychosine
341992 N-Octanoyl-beta-D-galactosylceramide
341991 N-Octadecanoyl-D3-sulfatide, deuterated
341990 N-辛酰基-beta-D-半乳糖酰基鞘氨醇 N-Octanoyl-beta-D-galactosylceramide
341989 N-Hexadecanoyl-sulfatide
341988 N-C16:0-D3-葡萄糖神经酰胺 N-Hexadecanoyl-D3-glucopsychosine, deuterated
34198738621-58-8lyso-Sulfatide (NH4+salt)
341986 N-乙酰神经鞘氨醇半乳糖苷 N-Acetyl-psychosine
34198552050-17-6Glucopsychosine
34198452050-17-6葡萄糖神经酰胺 Glucopsychosine
341982 葡萄糖脑苷脂 Glucocerebrosides
34198194885-04-8N-Hexanoyl-NBD-sphingosylphosphorylcholine (mixture of D-erythro and L-threo isomers)
341979 葡萄糖脑苷脂 Glucocerebrosides
341978 葡萄糖脑苷脂标准品 Glucocerebrosides
341977536-13-0半乳糖神经酰胺 Cerebrosides; Kerasin (top spot)
34197637211-11-3脑苷脂 Cerebrosides; Phrenosin (bottom spot)
341975 葡萄糖神经酰胺 Glucocerebrosides,Plant
34197485305-88-0半乳糖苷神经酰胺 Galactosylceramide (Galactocerebroside)
341973127593-21-9Methyl 3-hydroxyundecanoate
341972 Methyl 3-hydroxytridecanoate
34197194885-04-8荧光鞘磷脂 N-Hexanoyl-NBD-sphingosylphosphorylcholine

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