西美杰代理jena bioscience抗病毒核苷/核苷酸类似物--助力新型冠状病毒相关药物研发
持续近两个多月的新型冠状病毒感染的肺炎疫情牵动着每一个人的心，为了打赢这场疫情防控狙战，搞清致病机理，研发抗病毒相关药物和疫苗刻不容缓。Jena bioscience品牌有丰富的抗病毒核苷酸/核苷酸类似物，助力抗病毒的药物研发。
抗病毒核苷及核苷酸类似物主要有:
抗病毒核苷/核苷酸类似物可以通过抑制病毒复制的几个关键过程来抑制病毒繁殖，它们通过与天然的dNTP/NTP竞争结合到新的病毒核酸中，从而导致链终止或者诱变。在细胞培养实验中，可以用抗病毒核苷酸的非磷酸化核苷变体，这种核苷酸在细胞内被多种病毒和/或宿主激酶激活，从而发挥(tri)磷酸化形式的抗病毒作用。
西美杰代理jena bioscience抗病毒核苷/核苷酸类似物--助力新型冠状病毒相关药物研发
热销抗病毒核苷/核苷酸类似物：
货号 | 品名 | 规格 |
NU-1605S | 3TCMP | 10 μl (10 mM) |
NU-1605L | 3TCMP | 5 x 10 μl (10 mM) |
NU-1606S | 3TCTP | 5 μl (10 mM) |
NU-1606L | 3TCTP | 5 x 5 μl (10 mM) |
NU-1603S | d4TMP | 20 μl (10 mM) |
NU-1603L | d4TMP | 5 x 20 μl (10 mM) |
NU-1601S | AzTMP | 20 μl (10 mM) |
NU-1601L | AzTMP | 5 x 20 μl (10 mM) |
NU-989S | AzTTP | 10 μl (100 mM) |
NU-989L | AzTTP | 5 x 10 μl (100 mM) |
NU-875 | ara-Adenosine-5'-monophosphate (ara-AMP) | 2 mg |
NU-1111S | 50 μl (10 mM) | |
NU-1111L | ara-Adenosine-5'-triphosphate (ara-ATP) | 5 x 50 μl (10 mM) |
NU-876 | Acyclovir-5'-monophosphate | 2 mg |
NU-877 | Acyclovir-5'-triphosphate | 2 mg |
NU-021-2 | Ribavirin-5'-monophosphate | 2 mg |
NU-1105S | 20 μl (10 mM) | |
NU-1105L | Ribavirin-triphosphate | 5 x 20 μl (10 mM) |
N-DN-8234-100 | β-L-2'-Deoxythymidine | 100 mg |
NU-896S | 10 μl (100 mM) | |
NU-896L | 6-Aza-UTP | 5 x 10 μl (100 mM) |
NU-974 | Tenofovir | 100 mg |
NU-975 | Tenofovir-diphosphate | 1 mg |
NU-989S | 10 μl (100 mM) | |
NU-989L | AzTTP | 5 x 10 μl (100 mM) |
NU-275S | 10 μl | |
NU-275L | Ganciclovir-triphosphate | 5 x 10 μl |
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1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.
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