Recombinant human XRCC4
DNA double strand break repair and V(D)J recombination protein XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4; DNA repair protein XRCC4; DNA-repair protein XRCC4; X ray repair complementing defective repair in Chinese hamster cells 4 ; X ray repair cross complementing protein 4; X-ray repair complementing defective repair in Chinese hamster cells 4 ; X-ray repair cross-complementing protein 4; XRCC 4; XRCC-4; XRCC4_HUMAN.
浓度：1mg/ ml
来源：Recombinant Human
纯度：≥95% SDS-PAGE
表达系统：Escherichia coli
标签：His tag
蛋白长度：Full length protein
内毒素水平：<1.000 Eu/µg
纯化方法：HPLC
应用：SDS-PAGE，Western blot，ELISA
Biological activity,immunology research
保存：-20℃
保质期：1年
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
多克隆抗体
产品名称：Rabbit Anti-XRCC4 antibody
Rabbit Anti-XRCC4
别名：DNA double strand break repair and V(D)J recombination protein XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4; DNA repair protein XRCC4; DNA-repair protein XRCC4; X ray repair complementing defective repair in Chinese hamster cells 4 ; X ray repair cross complementing protein 4; X-ray repair complementing defective repair in Chinese hamster cells 4 ; X-ray repair cross-complementing protein 4; XRCC 4; XRCC-4; XRCC4_HUMAN.
来源：Rabbit
克隆类型：Polyclonal
浓度：1mg/ml
亚型：IgG
反应：Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
理论分子量：38kDa
免疫原：KLH conjugated synthetic peptide derived from human XRCC4
保存：-20℃
保质期：1年
多克隆抗体
产品名称：Anti-XRCC4 antibody
Mouse Anti-XRCC4
别名：DNA double strand break repair and V(D)J recombination protein XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4; DNA repair protein XRCC4; DNA-repair protein XRCC4; X ray repair complementing defective repair in Chinese hamster cells 4 ; X ray repair cross complementing protein 4; X-ray repair complementing defective repair in Chinese hamster cells 4 ; X-ray repair cross-complementing protein 4; XRCC 4; XRCC-4; XRCC4_HUMAN.
来源：Mouse
克隆类型：Monoclonal
浓度：1mg/ml
亚型：IgG
反应：Human
应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
反应: Human
理论分子量：38kDa
免疫原：KLH conjugated synthetic peptide derived from human XRCC4
保存：-20℃
保质期：1年
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
