Recombinant human WWOX
D16S432E; FOR; FOR II protein; FRA16D; Fragile 16D oxido reductase; fragile site FRA16D oxidoreductase; HHCMA 56; HHCMA56; PRO0128; putative oxidoreductase; WOX 1; WOX1; WW domain containing oxidoreductase; WW domain-containing protein WWOX; WWOX2; WWOX4; WWOX8; WWOX.
浓度：1mg/ ml
来源：Recombinant Human
纯度：≥95% SDS-PAGE
表达系统：Escherichia coli
标签：His tag
蛋白长度：Full length protein
内毒素水平：<1.000 Eu/µg
纯化方法：HPLC
应用：SDS-PAGE，Western blot，ELISA
Biological activity,immunology research
保存：-20℃
保质期：1年
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
多克隆抗体
产品名称：Rabbit Anti-WWOX antibody
Rabbit Anti-WWOX
别名：D16S432E; FOR; FOR II protein; FRA16D; Fragile 16D oxido reductase; fragile site FRA16D oxidoreductase; HHCMA 56; HHCMA56; PRO0128; putative oxidoreductase; WOX 1; WOX1; WW domain containing oxidoreductase; WW domain-containing protein WWOX; WWOX2; WWOX4; WWOX8; WWOX.
来源：Rabbit
克隆类型：Polyclonal
浓度：1mg/ml
亚型：IgG
反应：Human,Mouse,Rat
应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500
IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
理论分子量：46kDa
免疫原：KLH conjugated synthetic peptide derived from human WWOX
保存：-20℃
保质期：1年
单克隆抗体
产品名称：Anti-WWOX antibody
Mouse Anti-WWOX
别名：D16S432E; FOR; FOR II protein; FRA16D; Fragile 16D oxido reductase; fragile site FRA16D oxidoreductase; HHCMA 56; HHCMA56; PRO0128; putative oxidoreductase; WOX 1; WOX1; WW domain containing oxidoreductase; WW domain-containing protein WWOX; WWOX2; WWOX4; WWOX8; WWOX.
来源：Mouse
克隆类型：Monoclonal
浓度：1mg/ml
亚型：IgG
反应：Human
应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500
IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
反应: Human
理论分子量：46kDa
免疫原：KLH conjugated synthetic peptide derived from human WWOX
保存：-20℃
保质期：1年
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
