上海科敏生物销售c-Myb (D2R4Y) Rabbit mAb #12319 Cell Signaling，CST原装品质，*，订购c-Myb (D2R4Y) Rabbit mAb #12319 Cell Signaling，详情请咨询销售人员！
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产品名称：c-Myb (D2R4Y) Rabbit mAb #12319 Cell Signaling
货号：12319
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型：Monoclonal
规格：

抗体应用：

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on * sequence homology.
特异性/敏感度：c-Myb (D2R4Y) Rabbit mAb recognizes endogenous levels of total c-Myb protein.
来源及纯化方法：Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human c-Myb protein.
抗体背景：

c-Myb is a transcriptional activator that specifically recognizes the sequence 5'-YAAC[GT]G-3'. It is expressed in hematopoietic progenitor cells where it plays an important role in the control of proliferation and differentiation (1-3). c-Myb is required for transcription of genes involved in self-renewal of intestinal stem cells. Importantly, c-Myb regulates expression of Lgr5, a protein expressed in putative intestinal stem cells that give rise to all cell lineages of small intestinal crypts (4). c-Myb is reported to be expressed in colon crypt cells and in human colorectal cancer lines (5,6). Research has shown that c-Myb gene translocations and copy number alterations are found in several leukemias, breast cancer, and other solid tumors (7,8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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