上海科敏生物销售DLAT (4A4-B6-C10) Mouse mAb #12362 Cell Signaling，CST原装品质，*，订购DLAT (4A4-B6-C10) Mouse mAb #12362 Cell Signaling，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：DLAT (4A4-B6-C10) Mouse mAb #12362 Cell Signaling
货号：12362
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型：Monoclonal
规格：

抗体应用：

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on * sequence homology.
特异性/敏感度：DLAT (4A4-B6-C10) Mouse mAb recognizes endogenous levels of total DLAT protein.
来源及纯化方法：Monoclonal antibody is produced by immunizing animals with a recombinant human DLAT protein.
抗体背景：

Dihydrolipoamide acetyltransferase (DLAT) transfers an acetyl group from pyruvate to CoA to synthesize acetyl-CoA (1-4). This protein, also known as the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), has been implicated in the literature as the primary autoantigen in primary biliary cirrhosis (2-5). Antimitochondrial antibodies (AMAs) are likely formed when DLAT is exposed to the immune system in apoptotic cells of the bile duct (3,5). Research studies have shown that in some cases, cosmetics, NSAIDs, chewing gum, acetaminophen, and other compounds could trigger exposure of DLAT in sensitive individuals (3). The presence of AMAs is often detectable before disease diagnosis (4,5). Research studies have also shown that activation of the Toll-like receptor-3 (TLR-3) pathway is involved in the progression from a subclinical to clinical state (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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