- ¥8001起订
起订量：
Human Progranulin（PGRN）/颗粒体蛋白
- 型号
该企业相似产品
上海希美化学有限公司有限公司是一家专业代理销售生命科学基础研究以及临床检测等诸多领域的试剂、耗材、仪器的高科技企业。产品涉及分子生物学、免疫学、生命科学基础研究以及临床检测等诸多领域，同时我们提供专业的生物技术服务。
公司一方面注意跟踪世界范围分子生物学、细胞生物学等生物学科的发展前沿，努力将欧美专业生产厂家的具有*水平的产品*给各类研究人员；另一方面也非常重视自主产品研究和开发，推出了一系列具有竞争力的产品和服务。公司的经营原则是“质量*，诚信*，品牌*”，以“质量是企业的生命，诚信是经营的资本”为警醒 ,严把所售出商品的质量关。公司客户遍布大学、研究所、医院、卫生防疫、商品检验检疫、制药公司、生物技术公司和食品工业等单位。
公司在重视产品质量的同时，也建立了一套集技术支持、物流、售后服务等多个部门的*的服务体系，努力把我们方便、快捷、周到的服务提供给每一个客户。主要代理产品：试剂盒：ELISA试剂盒、免疫组化试剂盒、分子生物学试剂盒、细胞凋亡试剂盒。
ELISA KIT :CUSABIO品牌涵盖37个种属多达五千多种的Elisa试剂盒；拥有广泛的细胞因子、生长因子、趋化因子、激素、酶、病毒抗原和其他许多重组蛋白的蛋白表达系统。
化学试剂：*生化试剂、进口分装生化试剂、国产生化试剂。
抗体：进口原装抗体、进口分装抗体、单克隆抗体、多克隆抗体、一抗、二抗等等 进口代理品牌：
Sigma、 Peprotech 、Prospec 、eBioscience 、伯乐、 Invitrogen、 MBI、 Hyclone 、Cayman、CUSABIO、 Wako 、SantaCruz、epitomics、Gibco、R&D、Linco、abgent、Millipore、Innova Biosciences、Cst、Abcam
详细信息
Human PGRN
Progranulin Human Recombinant
颗粒体蛋白
Catalog No. CYT-524
Synonyms:
GRN, PGRN, granulin, Acrogranin, propithelin, PC cell derived growth Factor, GEP, GP88, PEPI, PCDGF.
Introduction:
A 88-kDa progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides and named granulin A （epithelin 1）, granulin B （epithelin 2）, granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Description:
Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88 kDa.
The Progranulin is purified by standard chromatographic techniques.
Source:
HEK 293 cells
Physical Appearance:
Sterile Filtered clear solution.
Formulation:
The protein solution contains 1x PBS.
Stability:
Progranulin although stable at 4°C for 3 weeks, should be stored at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Purity:
Greater than 90.0% as determined by:
（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE.
Biological Activity:
1. The effects of phospho-ERK1/2 and non phospho-ERK1/2 by human progranulin-FLAG in THP-1 cells.
To examine the signal of phospho-p44/42 MAPK and p44/42 MAP kinase, reactions were carried out at 37 degrees Celsius over 0, 30, 60, minutes, respectively by adding the recombinant protein （100ng/ml） to the THP-1 monocyte cell, which was maintained with serum starvation for 24hrs. Recombinant proteins in lanes 1, 2, and 3 were subjected to THP-1 monocyte cell treatments over 0, 30, 60mins, respectively.
2. The effects of phospho-ERK1/2 and non phospho-ERK1/2 by human progranulin-FLAG in MCF10A cells. To examine the signal of phospho-p44/42 MAPK and p44/42 MAP kinase, reactions were carried out at 37 degrees Celsius over 0, 10, 30, 60mins, respectively by adding the recombinant protein（500ng/ml） to the MCF10A human breast epithelial cells, which was maintained with serum starvation for 24hrs. Recombinant proteins in lanes 2, 3, and 4 were subjected to MCF10A human breast epithelial cell treatments over 0, 10, 30, 60mins, respectively.
Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
相关产品：
Periostin CYT-452 Recombinant Human Periostin
PGRN CYT-524 Recombinant Human Progranulin
Pleiotrophin 重组人多效生长因子 CYT-451 Recombinant Human Pleiotrophin
Placental Lactogen 重组人胎盘催乳素 CYT-656 Recombinant Human Placental Lactogen
bPlacental Lactogen 重组牛胎盘催乳素 CYT-511 Recombinant Bovine Placental Lactogen
oPlacental Lactogen 重组羊胎盘催乳素 CYT-512 Recombinant Ovine Placental Lactogen
cPlacental Lactogen 重组山羊胎盘催乳素 CYT-510 Recombinant Caprine Placental Lactogen
PLGF-1 重组人胎盘生长因子1 CYT-419 Recombinant Human Placenta Growth Factor-1
PLGF-2 重组人胎盘生长因子2 CYT-420 Recombinant Human Placenta Growth Factor-2
Prolactin 重组人催乳素 CYT-267 Recombinant Human Prolactin
Prolactin His 重组人催乳素 His CYT-493 Recombinant Human Prolactin, His Tag
mProlactin 重组小鼠催乳素 CYT-321 Recombinant Mouse Prolactin
rProlactin 重组大鼠催乳素 CYT-322 Recombinant Rat Prolactin
oProlactin 重组羊催乳素 CYT-240 Recombinant Ovine Prolactin
raProlactin 重组兔催乳素 CYT-513 Recombinant Rabbit Prolactin
Prl R GST 重组人催乳素受体GST CYT-469 Recombinant Human Prolactin Receptor, GST
Prl R 重组人催乳素受体 CYT-595 Recombinant Human Prolactin Receptor
raPrl R 重组兔可溶性受体催乳素 CYT-268 Recombinant Rabbit Prolactin Soluble Receptor
oPrl R 重组羊可溶性受体催乳素 CYT-293 Recombinant Ovine Prolactin Soluble Receptor
bPrl R 重组牛可溶性受体催乳素 CYT-294 Recombinant Bovine Prolactin Soluble Receptor
tPrl R 重组虹鳟可溶性受体催乳素 CYT-532 Recombinant Raibow Trout Prolactin Soluble Receptor
rPrl R 重组大鼠可溶性受体催乳素 CYT-533 Recombinant Rat Prolactin Soluble Receptor
oProlactin Antagonist 重组绵羊催乳素受体拮抗剂 CYT-311 Recombinant Ovine Prolactin Antagonist
