Recombinant Human CD3E&CD3D/CD3 epsilon &

93341ESRecombinant Human CD3E&CD3D/CD3 epsilon &

参考价: ¥4295

具体成交价以合同协议为准
2023-11-13 08:51:36
172
属性:
供货周期:两周;应用领域:医疗卫生,生物产业,制药;
>
规格:
100 μg;
>
产品属性
供货周期
两周
应用领域
医疗卫生,生物产业,制药
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Recombinant Human CD3E&CD3D/CD3 epsilon &

参考价: ¥4295

100 μg 4295元 99 件可售
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翌圣生物科技(上海)股份有限公司

翌圣生物科技(上海)股份有限公司

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产品简介

T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR

详细介绍

产品信息

 

产品名称

产品编号

规格

Recombinant Human CD3E&CD3D/CD3 epsilon & CD3 delta (His Tag)   

93341ES60

100 μg

93341ES76

500 μg

93341ES80

1 mg

 

产品描述

 

T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.

 

产品性质

 

别名(Synonyms)

CD3; CD3e; CD3E; CD3d; T3D; CD3D; CD3E&CD3D; CD3 delta&CD3 epsilon

Uniprot No.

P07766(CD3E)&P04234(CD3D)

表达区间及表达系统(Source

Recombinant Human CD3E&CD3D/CD3 epsilon&CD3 delta Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Asp23-Glu120 (CD3E)&Phe22-Ala105 (CD3D).

分子量(Molecular Weight)

The protein has a predicted MW of 17.9 kDa (CD3E) and 16.7 kDa (CD3D). Due to glycosylation, the protein migrates to 18-25 kDa based on Tris-Bis PAGE result.

外观(Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

纯度(Purity

95as determined by SDS-PAGE and HPLC

活性(Activity

1.ELISA DataImmobilized Human CD3E&CD3D at 2μg/ml (100μl/Well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 38ng/ml determined by ELISA.

2.ELISA DataImmobilized Human CD3E&CD3D at 2ug/ml (100μl/Well). Dose response curve for Foralumab, hFc Tag with the EC50 of 18.5ng/ml determined by ELISA.

内毒素(Endotoxin

1.0 EU per 1μg of the protein by the LAL method.

制剂(Formulation

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.

复溶(Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.

 

运输与保存方法

 

冰袋运输-20℃至-80存,一年有效期

复溶后,-20 至 -80°C,在未开封状态下保存 3-6 个月复溶后,2-8°C 保存 2-7 天。

建议第一次使用时分装冻存,避免反复冻融。

 

注意事项

 

1.避免反复冻融。

2.为了您的安全和健康,请穿实验服并戴一次性手套操作。

3.本产品仅作科研用途!

 

产品数据

 

Tris-Bis PAGE


  

Human CD3E&CD3D on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

 

SEC-HPLC

The purity of Human CD3E&CD3D is greater than 95% as determined by SEC-HPLC.

 

 

ELISA Data


Immobilized Human CD3E&CD3D at 2μg/ml (100μl/Well) on the plate. Dose response curve for OKT3, mFc Tag with the EC50 of 38ng/ml determined by ELISA.

 

ELISA Data

Immobilized Human CD3E&CD3D at 2ug/ml (100μl/Well).

Dose response curve for Foralumab, hFc Tag with the EC50 of 18.5ng/ml determined by ELISA.


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