产品描述

塔望科技开发的小动物头外置体积描记系统（Head-Out Plethysmography），采用特殊设计，使小动物的颈部与身体隔开，口鼻暴露在外面，实时测定容纳身体的腔室内气体容积与压力的变化。Glaab等对哮喘小鼠使用mACh激发后，取呼气中段流量(EF50 )下降55％时的mACh量( EF50)为指标来表示支气管反应的敏感性，研究证明，EF50和RL及CL有较好的相关性，可较好地反映呼吸系统的机械动力学改变。

产品特点

小动物头外置体积描记系统采用头外置式体积描记系统测量过程中，动物保持清醒状态，不需要麻醉，避免了创伤性气管切开术及麻醉的影响，使实验过程简便快捷，并适合长期跟踪研究。

另外系统可扩展连接雾化给药器，对动物进行雾化给药，建立咳嗽、哮喘等呼吸道疾病模型，系统可检测和记录激发过程中呼吸常规指标和气道高反应的变化，用以评价支气管收缩情况。

• 不需要做手术，操作简单。

• 动物处于清醒状态，结果不受麻醉和手术影响。

• 可以实现在同一只动物上做长期跟踪实验。

• 配备气溶胶雾化模块 。（可根据实验要求选配）

• 可联合同步测量其它信号，如体温、血压、心电信号等。

小动物头外置体积描记系统可连接口鼻暴露系统，实时在线监测动物肺功能指标的变化

检测参数

小动物头外置体积描记系统

Ti：吸气时间（s）

Te：呼气时间（s）

PIF：最大吸气流速（ml/s）

PEF：最大呼气流速（ml/s）

Volbal：吸气时间/呼气时间

F：呼吸频率（次/min）

Vt：潮气量（ml）

Mv：分钟通气量（ml）

AV：累积体积（ml）

EF50：呼出50%气量时对应的呼气流速（ml/s）

EIP：吸气末暂停时间

EEP：呼气末暂停时间

TR：松弛时间

PenH：增强呼气间歇（enhanced pause）

Rpef：相对时间

小动物头外置体积描记系统应用领域

哮喘Asthma

肺纤维化Lung Fibrosis

慢性阻塞性肺病COPD

急性呼吸系统疾病Acute Respiratory Disorders

模型开发Model Development

安全评估 Safety Assessment

毒理学Toxicology

小动物头外置体积描记系统型号选择

小动物头外置体积描记系统用户名单

小动物头外置体积描记系统相关文献

• [1]Sun Lingna,Fan Mingrui,Huang Dong,Li Bingqin,Xu Ruoting,Gao Feng,Chen Yanzuo. Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis[J]. Biomaterials,2021(prepublish):

• [2]李宁,李红鹏,张本炎,张柳,沈继敏,李庆云.高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制[J].中华医学杂志,2021,101(36):2893-2899.

• [3]Xiong Jiaying,Zhuang Tao,Ma Yurong,Xu Junyi,Ye Jiaqi,Ma Ru,Zhang Shuang,Liu Xin,Liu Bi-Feng,Hao Chao,Zhang Guisen,Chen Yin. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain[J]. European Journal of Medicinal Chemistry,2021,226:

• [4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang，Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance. Frontiers, 2022.819728:

• [5]Yumei Zhou,  Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang，Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma. Frontiers, 2022. 819747:

• [6]Rui Zheng, Wenhao Yang, Yuting Wen, Liang Xie, Fang Shi, Danli Lu, Jiaxin Luo, Yan Li, Ting Chen, Lina Chen, Wenming Xu and Hanmin Liu.Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.CDDpress.2022(13:559)：

• [7]Wenyang Wang, Min Mu, Yuanjie Zou, Bing Li,Hangbing Cao, Dong Hu and Xinrong Tao.Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.PeerJ,DOl 10.7717/2022：

  [8]Dongyi Zhu,Qian Zhang,Qinchuan Li,Guangxue Wang,Zhongliang Guo.Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway.The Journal Gene Medicine.First published: 26 July 2022:

• [9]Jiawen Zhou,Haiyun Chen,Qiuyi Wang,Sihan Chen,Rong Wang,Ziyang Wang,Cuicui Yang,Ao Chen,Jingyu Zhao,Zihao Zhou,Zhiyuan Mao,Guoping Zuo,Dengshun Miao,Jianliang Jin.Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription.Aging Cell WILEY.First published: 30 July 2022：

• [10]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.Institute of Special Environmental Medicine, Nantong University, Nantong, 226019, China.Received 7 March 2022, Revised 27 June 2022, Accepted 30 June 2022, Available online 3 July 2022, Version of Record 12 July 2022.

• [11]Mengjun Zhanga,Huiyang Jiang,Lan Wu,Haoyu Lu,Hriday Bera,Xing Zhao,Xiong Guo,Xulu Liu,Dongmei Cun,Mingshi Yang.Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment.Journal of Controlled Release Volume 352, December 2022.

• [12]Xue Lu,Zhu-Xia Tan,Wen-Jing Wang,Ping Zhan,Yan Wang,Lin Fu,Lan Gao,Hui. Zhao,Hua Wang,De-Xiang Xu.Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice.Environmental Pollution Volume 315, 15 December 2022, 120462

• [13]Gu, W., Lei, J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma. Mol Biol Rep 49, 9283–9296 (2022).

*我公司可以根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务。