<2400> 人毛乳头细胞（HHDPC） 提取于人毛乳头组织，于*代冻存。
 
    毛乳头是细胞中高活性的团体。它来源于真皮的间叶细胞，位于毛囊的基部。毛乳头能控制头发生长周期，诱导表皮毛囊发育并生成毛发纤维。培养早期，毛乳头细胞能诱导毛发体外生长，但进一步培养，该特性消失。毛发生长受到毛囊细胞与间叶上皮细胞间相互作用的调节。例如：毛乳头细胞分泌的β干扰素抑制体外培养中外根鞘细胞的生长。毛乳头细胞的存在也受到信号转导途径的影响，激活的ERK和Akt促进毛乳头细胞的存活。

    人毛乳头细胞（HHDPC） 提取于人毛乳头组织，于*代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过Fibronectin and CD105免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
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储存：液氮

运输：干冰

用途：科研

The dermal papilla is a highly active group of cells. It is derived from the dermis mesenchyme, located at the base of the hair follicle. The dermal papilla is implicated in controlling the hair growth cycle, be capable of inducing follicle development from the epidermis and production of hair fiber. Early passage dermal papilla cells can induce hair growth in vivo, but, upon further culturing, this property is lost [1]. Hair growth is tightly regulated by the epithelial-mesenchymal interaction of hair follicle cells, for example, interferon beta secreted from dermal papilla cells inhibits the growth of outer root sheath cells in cultured [2]. The survival of dermal papilla cell is also regulated by signal transduction pathways, activating both ERK and Akt promote dermal papilla cell survival [3].

HHDPC from ScienCell Research Laboratories are isolated from dermal papilla of human hair follicles. HHDPC are cryopreserved at passage one culture and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HHDPC are characterized by their mesenchymal cell morphology and immunofluorescent method with antibody to fibronectin and CD105. HHDPC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HHDPC are guaranteed to further expand for 15 population doublings at the condition provided by ScienCell Research Laboratories.

Reference
[1] Filsell, W., Little, J.C., Stones, A.J., Granger, S.P. and Bayley, S.A. （1994） Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype. Journal of Cell Science 107:1761-1772.
[2] Kim, C.D., Choe, Y., Shim, C., Kim, K. （2002） Interferon Beta secreted from human hair dermal papilla cells inhibits the growth of outer root sheath cells cultured in vitro. Biochem Biophys Res Commun. 290:1133-8.
[3] Han, J.H., Kwon, O.S., Chung, J.H., Cho, K.H., Eun, H.C., Kim, K.H. （2004） Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. J Dermatol Sci. 34:91-8.