美国Seracare HIV-1血清阳转盘（HIV-1 SC Pnl P）

广州健仑生物科技有限公司

SeraCare Life Sciences公司主要在美国、欧洲和亚洲提供促进人类和动物诊断和治疗学的探索、开发和生产的产品和服务。其业务分为两个部分：诊断和生物制药产品和生物服务。诊断和生物制药产品部门生产和销售诊断和控制面板产品，用于测试传染性疾病的临床实验室及员工培训和能力测试。生物服务部门提供生物银行、来样加工和测试服务。

美国SeraCare收购BBI公司，即原BBI血清盘已经改名为SeraCare血清盘。

其产品包括有：传染病阳性质控品、疾病标准品、细菌阳性质控品、人血清白蛋白、人伽马球蛋白、牛血清白蛋白、血清盘、人血浆、人血清。

SeraCare的血清盘包括：HIV-1转化盘、HIV性能盘、HBV转化盘、HBV性能盘、HCV转化盘、HCV性能盘、弓形虫性能盘、线性盘和质控盘等等。

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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美国Seracare HIV-1血清阳转盘（HIV-1 SC Pnl P）

美国Seracare 

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【公司名称】 广州健仑生物科技有限公司

【市 场 部】    杨永汉

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【腾讯Q Q】 2042552662

【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

目前，一些已有的癌症治疗方法需要在实验室制造抗体与癌细胞中的蛋白质结合，使其能够被患者免疫系统摧毁，这个过程既耗时又昂贵。韦斯教授称，他们的发现可以极大地促进抗体的生产效率，而且费用会更少。
该技术在其他生物技术领域及食品生产领域也有很大的应用价值。目前，加州大学欧文分校已经为该技术申请了，并将很快投入市场。
近日，生物学期刊the journal of BioLogical chemistry在线发表了来自美国科学家的一项zui近研究成果。研究人员发现机体能量水平能够通过视黄醇脱氢酶调控全反式维甲酸的生物合成，通过实验证明了全反式维甲酸与胰岛素信号途径的相互关系。这一研究成果对研究胰岛素相关疾病如二型糖尿病等具有一定意义。
全反式维甲酸(atRA)是一种来自视黄醇(维生素A)的自体有效物质，它能够调节能量平衡减少肥胖。Kristin M. Obrochta等人发现atRA的合成会受到机体能量水平的调节，这种作用主要是通过调节视黄醇脱氢酶(Rdh)的表达实现的。研究人员在给小鼠饥饿再进食6小时后发现，与饥饿16小时的小鼠相比，肝脏和棕色脂肪中Rdh1的表达水平下降了约80%~90%，在肝脏,胰腺和肾脏中Rdh10的表达下降了约45%~63%，同时发现肝脏内atRA的表达水平也下降。口服葡萄糖或腹腔注射胰岛素都会导致肝脏内Rdh1和Rdh10表达下降50%。
研究人员通过体外细胞培养发现，移除培养基中的血清，会增加Rdh10和Rdh16(小鼠Rdh1的同源蛋白)表达，但进行胰岛素刺激后，Rdh10和Rdh16的表达水平又发生下降。通过对机制探讨发现能量水平可以通过胰岛素和Foxo1调节Rdh表达以及atRA的生物合成。

At present, some existing cancer treatment methods require that the antibodies in the laboratory be combined with the proteins in the cancer cells so that they can be destroyed by the patient's immune system. This process is time-consuming and expensive. Professor Weiss said that their discovery can greatly promote the efficiency of antibody production, and the cost will be less.
The technology also has great application value in other areas of biotechnology and food production. Currently, the University of California, Irvine, has applied for a patent for this technology and will soon be on the market.
Recently, the journal of Biological chemistry, an international journal of biological sciences, published a recent research result from American scientists. The researchers found that the energy level of the body can modulate the biosynthesis of all-trans retinoic acid through retinol dehydrogenase, and the relationship between all-trans retinoic acid and the insulin signaling pathway was proved through experiments. This research result has certain significance for the study of insulin-related diseases such as type 2 diabetes.
All-trans retinoic acid (atRA) is an autologous substance derived from retinol (vitamin A) that regulates energy balance and reduces obesity. Kristin M. Obrochta et al. found that the synthesis of atRA is regulated by the body's energy level, which is mainly achieved by regulating the expression of retinol dehydrogenase (Rdh). The researchers found that after 6 hours of starvation and feeding of mice, the expression levels of Rdh1 in liver and brown fat were reduced by about 80% to 90% compared to mice that were hungry for 16 hours, Rdh10 in the liver, pancreas and kidneys. The expression decreased by approximay 45% to 63%, and it was also found that the level of atRA in the liver also decreased. Oral glucose or intraperitoneal injections of insulin all cause a 50% decrease in the expression of Rdh1 and Rdh10 in the liver.
Using in vitro cell culture, the researchers found that removing the serum from the culture medium increased the expression of Rdh10 and Rdh16 (a homolog of mouse Rdh1), but after insulin stimulation, the expression levels of Rdh10 and Rdh16 decreased again. By investigating the mechanism for the discovery of energy levels, Rdh expression and atRA biosynthesis can be regulated by insulin and Foxo1.