起订量:
UMOD/人尿调制蛋白
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公司一方面注意跟踪世界范围分子生物学、细胞生物学等生物学科的发展前沿,努力将欧美专业生产厂家的具有*水平的产品*给各类研究人员;另一方面也非常重视自主产品研究和开发,推出了一系列具有竞争力的产品和服务。公司的经营原则是“质量*,诚信*,品牌*”,以“质量是企业的生命,诚信是经营的资本”为警醒 ,严把所售出商品的质量关。公司客户遍布大学、研究所、医院、卫生防疫、商品检验检疫、制药公司、生物技术公司和食品工业等单位。
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ELISA KIT :CUSABIO品牌涵盖37个种属多达五千多种的Elisa试剂盒;拥有广泛的细胞因子、生长因子、趋化因子、激素、酶、病毒抗原和其他许多重组蛋白的蛋白表达系统。
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Sigma、 Peprotech 、Prospec 、eBioscience 、伯乐、 Invitrogen、 MBI、 Hyclone 、Cayman、CUSABIO、 Wako 、SantaCruz、epitomics、Gibco、R&D、Linco、abgent、Millipore、Innova Biosciences、Cst、Abcam
UMOD Human | |
Catalog No. ENZ-381 |
Synonyms:
Tamm-Horsfall urinary glycoprotein, THP, FJHN, HNFJ, THGP, MCKD2, ADMCKD2, UMOD, Uromodulin.
Introduction:
Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.
Source:
Human Urine.
Physical Appearance:
Filtered White lyophilized (freeze-dried) powder.
Formulation:
The UMOD protein was lyophilized from 0.4μm filtered solution at a concentration of 0.6mg/mL containing water.
Solubility:
Add deionized water to prepare a working stock solution of approximay 0.5mg/mL and let the lyophilized pellet dissolve compley. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:
Lyophilized UMOD although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution UMOD should be stored at 4°C between 2-7 days and for future use below
-18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity:
Greater than 95.0% as determined by SDS-PAGE.
Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.