Chlorotoxin（蝎氯毒素 氯代毒素） 

Selective ligand of Glioma cells(神经胶质瘤细胞的选择性配体)

Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chlorotoxin binds to Cl^-channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl^- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl^- channels participate in chlorotoxin binding. It was demonstrated that chlorotoxin inhibits specifically the activity of matrix metalloproteinase-2 (MMP-2) without affecting MMP-1, MMP-3 and MMP-9. MMP-2 are upregulated in glioma cells and related cells making chlorotoxin a promising antitumoral drug and diagnosis tool.

Chlorotoxin 技术资料

氨基酸序列：

Met-Cys²-Met-Pro-Cys⁵-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys¹⁶-Asp-Asp-Cys¹⁹-Cys²⁰-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys²⁸-Tyr-Gly-Pro-Gln-Cys³³-Leu-Cys³⁵-Arg-NH₂ 

二硫键：Cys²-Cys¹⁹, Cys⁵-Cys²⁸, Cys¹⁶-Cys³³ and Cys²⁰-Cys³⁵ 

长度 (aa)： 36

分子式： C₁₅₈H₂₄₉N₅₃O₄₇S₁₁ 

分子量： 3995.8 Da

外观：White lyophilized solid

可溶性：water and saline buffer

CAS 号：[163515-35-3]

来源：Synthetic 

纯度：> 95 %

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