Huwentoxin-I（虎纹捕鸟蛛神经毒素-I） 

Blocker of N-type Ca²⁺ channel and TTX-S channels

N型钙通道和TTX敏感型(TTX-S)通道阻断剂

                    TTX- S: 细胞河豚毒素敏感型钠电流

Huwentoxin-I (HwTx-I) is a neurotoxin that was originally isolated from the venom of the Chinese bird spider Ornithoctonus huwena. Huwentoxin-I is known to be an inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC₅₀ ~ 50 nM) and N-type voltage-sensitive calcium channels (IC₅₀ ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels.  The selectivity  of Huwentoxin-I  for calcium channels appears to be higher than  ω-conotoxin MVIIA and equivalent to  ω-conotoxin GVIA. Huwentoxin-I demonstrated an antinociceptive effect in the rat model of the formalin test when administrated intrathecally (ED₅₀ ~ 0.28 µg/kg), without side effects of the ones led by  ω-conotoxin MVIIA.

Huwentoxin-I 技术资料

氨基酸序列：

 Ala-Cys²-Lys-Gly-Val-Phe-Asp-Ala-Cys⁹-Thr-Pro-Gly-Lys-Asn-Glu-Cys¹⁶-Cys¹⁷-Pro-Asn-Arg-Val-Cys²²-Ser-Asp-Lys-His-Lys-Trp-Cys²⁶-Lys-Trp-Lys-Leu-OH 

二硫键： Cys²-Cys¹⁷, Cys⁹-Cys²² and Cys¹⁶-Cys²⁹  

长度 (aa)：33 

分子式：C₁₆₈H₂₅₀N₄₆O₄₁S₆ 

分子量： 3751.77 Da 

外观：White lyophilized solid 

可溶性：water and saline buffer 

CAS 号：not available 

来源： Synthetic  

纯度： > 97 %

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