Huwentoxin-IV（虎纹捕鸟蛛神经毒素-IV）  

TTX-S selective blocker(电压门控钠离子通道TTX-S选择性阻断剂)

Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC₅₀ of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNa_v1.7 (SCN9A, IC₅₀ is 26 nM), rNa_v1.2 (SCN2A, IC₅₀ is 150 nM), and rNa_v1.3 (SCN3A, IC₅₀ is 338 nM), compared with muscle subtypes rNa_v1.4 (SCN4A) and hNa_v1.5 (SCN5A) (IC₅₀ is > 10 µM).Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.

Huwentoxin-IV（虎纹捕鸟蛛神经毒素-IV）技术资料

氨基酸序列：

Glu-Cys²-Leu-Glu-Ile-Phe-Lys-Ala-Cys⁹-Asn-Pro-Ser-Asn-Asp-Gln-Cys¹⁶-Cys¹⁷-Lys-Ser-Ser-Lys-Leu-Val-Cys²⁴-Ser-Arg-Lys-Thr-Arg-Trp-Cys³¹-Lys-Tyr-Gln-Ile-NH₂ 

二硫键：Cys²-Cys¹⁷, Cys⁹-Cys²⁴ and Cys¹⁶-Cys³¹ 

长度 (aa)：35 

分子式：C₁₇₄H₂₇₇N₅₁O₅₂S₆ 

分子量：4109.18 Da 

外观：White lyophilized solid 

可溶性： water and saline buffer 

CAS 号：not available 

来源：Synthetic  

纯度：> 97 %

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